Coffee..

 

“Coffee is consumed by large segments of the world population,” study collaborator Robert S. Chapkin,  “It has well-documented salutary effects in humans, similar to the Mediterranean diet.”

“What we’ve shown is that some of those effects may be linked to how coffee compounds interact with this receptor, which is involved in protecting the body from stress-induced damage.”

Chapkin told Newsweek that NR4A1 is a “nuclear receptor,” with which small molecules in coffee can engage. Chapkin compared it to a key being inserted into a lock.

“NR4A1 is the lock and coffee contains the keys,” Chapkin said. “Once NR4A1 is bound by coffee-derived small molecules, e.g., caffeic acid, chlorogenic acid and ferulic acid, its ability to bind to DNA and regulate the expression of select genes (in the cell nucleus) is modulated.

“This partly explains how coffee can improve human health and reduce the risk of several chronic diseases of aging.”