Over the past several months, a series of studies has found that some people mount an extraordinarily powerful immune response against SARS-CoV-2.
Their bodies produce very high levels of antibodies, but they also make antibodies with great flexibility likely capable of fighting off the variants of coronavirus circulating in the world but also likely effective against variants that may emerge in the future.
People who have had a "hybrid" exposure to the virus. Specifically, they were infected with COVID-19 in 2020 and then immunized with mRNA vaccines this year.
"Those people have amazing responses to the vaccine," says virologist Theodora Hatziioannou at the Rockefeller University.
"I think they are in the best position to fight the virus. The antibodies in these people's blood can even neutralize SARS-CoV-1, the first coronavirus, which emerged 20 years ago. That virus is very, very different from SARS-CoV-2."
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