The study investigated 23 cognitively normal, relatively young older adults with a family history or genetic risk for Alzheimer Disease . All patients had a sedentary lifestyle.
They underwent a battery of assessments, including cardiorespiratory fitness testing, measurement of daily physical activity, brain glucose metabolism imaging (a measure of neuronal health), and cognitive function tests.
They underwent a battery of assessments, including cardiorespiratory fitness testing, measurement of daily physical activity, brain glucose metabolism imaging (a measure of neuronal health), and cognitive function tests.
Half of the participants were to receive information. The other half participated in a moderate intensity treadmill training program with a personal trainer, three times per week for 26 weeks.
The participants’ improved cardiorespiratory fitness was associated with increased brain glucose metabolism in the posterior cingulate cortex, an area of the brain linked to Alzheimer Disease.
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